Table 3.
Major clinical events in type 2 diabetic patients with renal insufficiency stratified by attainment of ≥3 prespecified treatment targets after 2 years of follow-up
| Attained ≥3 treatment goals* | Attained ≤2 treatment goals* | P† | |
|---|---|---|---|
| n | 91 | 114 | |
| Composite primary end point | 14 | 34 | 0.04 |
| Dialysis | 6 | 12 | 0.28 |
| ESRD (Cr >500 μmol/l) | 10 | 21 | 0.14 |
| Death | 4 | 15 | 0.11 |
| Composite cardiovascular end point | 19 | 21 | 0.22 |
| Hospitalization for heart failure | 12 | 16 | 0.77 |
| Hospitalization for arrhythmia | 4 | 2 | 0.41 |
| Acute myocardial infarction | 3 | 5 | 0.97 |
| Revascularization (PTCA/CABG) | 1 | 1 | 0.83 |
| Hospitalization for angina | 0 | 1 | 0.31 |
| Other revascularization | 0 | 1 | 0.99 |
| Lower-limb amputation | 1 | 0 | 0.14 |
Data are n.
*Treatment targets: 1) blood pressure <130/80 mmHg, 2) A1C <7%, 3) LDL cholesterol <2.6 mmol/l, 4) fasting plasma triglyceride <2 mmol/l, and 5) treatment with ACE inhibitors and/or ARBs.
†After adjustment for age, sex, and study centers. CABG, coronary artery bypass graft; Cr, serum creatinine; PTCA, percutaneous transluminal coronary angioplasty.