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. 2005 Aug 3;25(31):7101–7110. doi: 10.1523/JNEUROSCI.5258-04.2005

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Copyright © 2005 Society for Neuroscience 0270-6474/05/257101-10.00/0

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Figure 2. — Inhibition of system selectively reduces cystine uptake and depletes intracellular glutathione in glioma cells. a, Coincubation with (S)-4-CPG and sulfasalazine (SAS) reduced cystine uptake in glioma cell lines and in a primary glioma cell culture (GBM62). b, Sulfasalazine affects cystine uptake into cortical astrocytes to a much lesser extent than up take into D54-MG glioma cells. c, Cystine uptake in cortical neurons was negligible compared with astrocytes orglioma cells. d, Sulfasalazine caused a time- and dose-dependent decrease in intracellular glutathione in D54-MG cells. e, Intracellular level of glutathione in astrocytes is significantly less affected by sulfasalazine. f, Treatment with (S)-4-CPG sulfasalazine depleted intracellular glutathione in glioma cells but not cortical astrocytes or neurons. Error bars indicate SE.

Inline graphic — Inhibition of system selectively reduces cystine uptake and depletes intracellular glutathione in glioma cells. a, Coincubation with (S)-4-CPG and sulfasalazine (SAS) reduced cystine uptake in glioma cell lines and in a primary glioma cell culture (GBM62). b, Sulfasalazine affects cystine uptake into cortical astrocytes to a much lesser extent than up take into D54-MG glioma cells. c, Cystine uptake in cortical neurons was negligible compared with astrocytes orglioma cells. d, Sulfasalazine caused a time- and dose-dependent decrease in intracellular glutathione in D54-MG cells. e, Intracellular level of glutathione in astrocytes is significantly less affected by sulfasalazine. f, Treatment with (S)-4-CPG sulfasalazine depleted intracellular glutathione in glioma cells but not cortical astrocytes or neurons. Error bars indicate SE.