A. Saggital section of greater activation in the left anterior insula (−36, 6, 6, Z = 3.92, P uncorrected <.001) in response to anticipatory food reward in obese compared to lean subjects with B. the bar graphs of parameter estimates from that region. C. Sagittal section of greater activation in the Rolandic operculum (54, −12, 33, Z = 5.95, P uncorrected <.001) in response to consummatory food reward in obese compared to lean subjects with D. the bar graphs of parameter estimates from that region. Note: *p<.05; **p<.001.