Figure 3.

Location of the gene for Sema W in humans and mice. The human SEMAW gene was localized between markers WI-5987 and GCT1B4 by radiation hybrid mapping. The locations of disease loci for Parkinson’s disease and Alström’s syndrome are shown along with the approximate locations of microsatellite markers that define their limits. The relative locations of the markers shown are based on the radiation hybrid map of the human genome mapping project (52). The mouse Semaw gene was localized between markers D6Mit71 and D6Mit9 by radiation hybrid mapping, and nearby markers D6Mit189 and D6Mit70 and the gene Dok were localized by physical mapping. The approximate locations of disease loci of cerebellar deficient folia (cdf), mnd2, and truncate (tc) are shown relative to the mapped markers. cR, centirays.