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. Author manuscript; available in PMC: 2009 May 13.
Published in final edited form as: Neuropsychologia. 2009 Feb 2;47(5):1213–1226. doi: 10.1016/j.neuropsychologia.2009.01.031

Table 3.

Summary of studies examining rule shifting in PD

Source Task Patient sample Result
Beatty & Monson, 1990 WCST (Heaton et al., 1993) 27 PD Stages 1–4; M=2.6 PD = NC (d=.34)
Beatty, 1989 WCST (Heaton et al., 1993) 43 PD; Stages 1–4 PD = NC (d =.56)
Beatty, Staton, Weir & Monson, 1989 WCST (Heaton et al., 1993) 25 PD; Stages 2–3 PD = NC (d =.43)
Bowen, Kamienny, Burns & Yahr, 1975 WCST (Berg, 1948) 18 PDOFF
53 PDON
PDOFF = NC
PDON = NC
Canavan et al., 1989 WCST (Nelson, 1976) 19 PD; M = 1.5 PD < NC
Channon, Jones, & Stephenson, 1993 Unidimensional classification learning 12 PD Stages 2–3, M = 2.75 PD < NC (d =.50)
Cools, van den Bercken, Horstink, van Spaendonck, & Berger, 1984 Block sorting task 18 PD Stages 1–4; M = 2.3 PD < NC
Cools, Barker, Sahakian & Robbins, 2001 ID/ED task (Downes et al., 1989 14 PDON; M = 1.75
15 PDOFF; M = 1.80
PDOFF = PDON < NC
Cooper, Sagar, Jordan, Harvey, & Sullivan, 1991 WCST (Milner, 1963) 60 PD; newly diagnosed;
unmedicated
PD = NC (d =.43)
Cooper, Sagar, Jordan, Harvey, Sullivan, 1992 WCST(Heaton et al., 1981) 82 newly diagnosed PD;
randomly assigned on or off meds
PD = NC in each case
Dalrymple-Alford, Kaldters, Jones, & Watson, 1994 WCST (Heaton et al., 1993) 8 PD PD = NC (d = 0)
Downes et al., 1989 ED/ID task 16 PDOFF M = 1.1
6 PDON M = 2.4
PDOFF < NC
PDON < NC
Fimm, Barti, Zimmerman & Wallesch, 1994. modified ID/ED task 19 PDON Stages 2–3 M=2;
8 PDOFF Stages 1–3; M= 2.
PDON = NC;
PDOFF < NC
Gauntlett-Gilbert, Roberts & Brown, 1999 modified ID/ED task 10 PD Stages 1–3; M=2.2 PD < NC
Gotham, Brown & Marsden, 1988 WCST (Nelson, 1976) 16 PD Compared ON and OFF PDON < NC (d =.90)
PDOFF < NC (d = 1.1)
Green, 2002 WCST (Heaton et al., 1993) 61 PDOFF; Stage 3–4 PDOFF < NC
Kulisevsky et al., 1996. WCST (Heaton et al., 1993) 20 PD Compared ON and OFF PDON = NC
PDOFF = NC
Lange, Robbins, Marsden, Owen & Paul, 1992 ID/ED task (Downes et al., 1989) 10 PD Stages 3–5, M = 3.5;
Compared ON and OFF
PDOFF = PDON < NC
Lees & Smith, 1983 WCST (Neslon, 1976) 12 PD PD = NC
Lewis et al., 2005 Modified ID/ED task 20 PD; M = 1.9
Compared ON and OFF
PDOFF = PDON < NC
Monchi et al., 2004 WCST 8 PDOFF PDOFF < NC
Owen et al., 1993 ID/ED task (Downes et al., 1989) 26 PDOFF (stages 1–3)
23 PDON (stages 1–4)
PDOFF < NC (d= 2.4)
PDON = NC
Paolo, Troester, Axelrod & Kaller, 1995 WCST (Heaton et al., 1993) 181 PD Stage 1–4 PD < NC (d= 1.03)
Price, 2006 WCST (Hart et al., 1998 17 PD Stages 1–4, M = 2.3 PD = NC
Slabosz et al., 2006 Modified ID/ED task 20 PD Stage M = 1.9
Compared ON and OFF
PDOFF = PDON < NC
Starkstein et al., 1989 WCST (Heaton et al., 1993) 48 mild PD; 20 moderate PD
26 severe PD
severe < moderate < mild PD; mild PD = NC
Tomer, Aharon-Peretz, & Tsitrinbaum, 2007 ID/ED task of CANTAB (Robbins et al., 1998) 35 PD PD < NC (d = 1.08)
van Spaendonck, Berger, Horstink, Brom, & Cools, 1995 WCST and 2 variants (follwing Nelson, 1976) 45 PD PD = NC
Witt et al., 2006 WCST (version not given) 20 PD Stages 1–3 PD = NC
Zakzanis & Freedman WCST (Heaton et al. et al., 1993) Meta-analysis (N= 11) mean(d) =.46
Range(d) = −.66 − +.92

Note. Stages refers to Hoehn & Yahr (1967) ratings of PD severity; M = mean level of PD severity; d = Cohen’s d measure of effect size