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. Author manuscript; available in PMC: 2010 Feb 1.

Published in final edited form as: J Mol Cell Cardiol. 2008 Nov 11;46(2):201–212. doi: 10.1016/j.yjmcc.2008.10.025

Fig. 2 — Characterization of PGC-1α, ERRα target1, and ERRα target 2 core enrichment sets defined by the DCM/ICM vs. NF comparison. (A) Upper plot depicts the enrichment profile in green of the ‘PGC-1α targets’ pathway by Gene Set Enrichment Analysis (GSEA). The arrow denotes the point of maximal deviation of the Enrichment Score (ES) from the baseline, which is determined by genes of the ‘Core Enrichment Set’ (CES). Lower plot shows all 17,419 genes rank-ordered according to the signal-to-noise metric, with the dotted line demarcating genes that are positively (red) and negatively (blue) correlated with heart failure. (B) Comparative functional distributions using GO Biological Process terms of the 158 genes of the PGC-1α target CES, the 24 genes of the ERRα target 1 CES, and the 38 genes of the ERRα target 2 CES.

Fig. 2 — Characterization of PGC-1α, ERRα target1, and ERRα target 2 core enrichment sets defined by the DCM/ICM vs. NF comparison. (A) Upper plot depicts the enrichment profile in green of the ‘PGC-1α targets’ pathway by Gene Set Enrichment Analysis (GSEA). The arrow denotes the point of maximal deviation of the Enrichment Score (ES) from the baseline, which is determined by genes of the ‘Core Enrichment Set’ (CES). Lower plot shows all 17,419 genes rank-ordered according to the signal-to-noise metric, with the dotted line demarcating genes that are positively (red) and negatively (blue) correlated with heart failure. (B) Comparative functional distributions using GO Biological Process terms of the 158 genes of the PGC-1α target CES, the 24 genes of the ERRα target 1 CES, and the 38 genes of the ERRα target 2 CES.