. Author manuscript; available in PMC: 2010 Feb 1.

Published in final edited form as: J Mol Cell Cardiol. 2008 Nov 11;46(2):201–212. doi: 10.1016/j.yjmcc.2008.10.025

Table 3.

PGC-1α, ERRα, and ERK CES genes predict Failing vs. Non-failing Phenotypes

		Unmatched (Test) Population	Matched (Training) Population
PGC-1α Target CES	Correct/Total	34/42 (80.9%)	49/49 (100%)
	Sensitivity	96.0%
	Specificity	58.8%
ERRα Target 1 CES	Correct/Total	32/42 (76.2%)	49/49 (100%)
	Sensitivity	96.0%
	Specificity	47.1%
ERRα Target 2 CES	Correct/Total	26/42 (63.4%)	49/49 (100%)
	Sensitivity	84.0%
	Specificity	29.4%
ERK Pathway CES	Correct/Total	31/42 (73.8%)	49/49 (100%)
	Sensitivity	88.0%
	Specificity	52.9%
Significant Markers (FWER<0.05)	Correct/Total	36/42 (85.7%)	49/49 (100%)
	Sensitivity	92.0%
	Specificity	76.5%

Results of KNN prediction models using the PGC-1α target, ERRα target 1, ERRα target 2, and ERK pathway CES genes vs. the most significantly differentially expressed markers at FWER < 0.05 are shown, including the ratio of samples correctly assigned by the model, as well as sensitivity and specificity. CES, ‘core enrichment set’ by Gene Set Enrichment Analysis.