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. Author manuscript; available in PMC: 2009 Dec 31.
Published in final edited form as: J Am Chem Soc. 2008 Dec 31;130(52):17913–17927. doi: 10.1021/ja806629e

Scheme 10.

Scheme 10

Synthesis of 8-fluorosancycline (38) by Michael–Claisen cyclization using benzylic bromide 37 and enone 1 as substrates, and an in situ protocol for lithium-halogen exchange, followed by deprotection.