Skip to main content
. Author manuscript; available in PMC: 2009 Dec 31.
Published in final edited form as: J Am Chem Soc. 2008 Dec 31;130(52):17913–17927. doi: 10.1021/ja806629e

Scheme 7.

Scheme 7

Synthesis of 7-aza-10-deoxysancycline (30) by Michael–Claisen cyclization using phenyl ester 28 and enone 1 as substrates, with deprotonation in situ, followed by deprotection.