. Author manuscript; available in PMC: 2009 Dec 31.

Published in final edited form as: J Am Chem Soc. 2008 Dec 31;130(52):17913–17927. doi: 10.1021/ja806629e

Table 5.

In vivo efficacy of selected tetracycline analogs in a tetracycline-sensitive strain of S. aureus.

Compound	Number of Mice	Number of Deaths at Dose of					ED₅₀ (mg/kg)
Compound	Number of Mice	30 mg/kg	10 mg/kg	3 mg/kg	1 mg/kg	0.3 mg/kg	ED₅₀ (mg/kg)
	6		0	0	2	6	0.97
	6	0	5	6	6	6	10.71
	6	0	0	1	6	6	2.80
	6	0	0	1	5	6	1.73
	6	0	0	1	5	6	1.73

Mice were inoculated intraperitoneally with an LD₉₀₋₁₀₀ bolus of Staphylococcus aureus (Smith) (3.5 × 10⁵ CFU/mouse) in 0.5 mL of BHI broth containing 5% mucin. Tetracycline analogs were administered intravenously to test animals at one hour after bacterial inoculation. Mortality was monitored once daily for 7 days.