Table 2.
The impact of DHEA treatment on lipoprotein profiles
| Lipoproteins | Placebo median change (interquartile range) | DHEA median change (interquartile range) | P value |
|---|---|---|---|
| NMR triglycerides (mg/dl) | 2.0 (−4, 35) | −5 (−26, 06) | 0.076 |
| NMR total cholesterol (mg/dl) | 20.0 (−3, 36) | −22 (−34, 6) | 0.021 |
| VLDL mean particle size (nm) | −0.3 (−2.0, 2.3) | −2.3 (−3.7, −0.2) | 0.101 |
| LDL mean particle size (nm) | −0.1 (−0.2, 0.0) | −0.1 (−0.2, 0.1) | 0.889 |
| HDL mean particle size (nm) | 0.0 (−0.1, 0.1 ) | −0.1 (−0.2, 0.0) | 0.129 |
| NMR VLDL triglycerides (mg/dl) | 2 (−13, 24) | −3 (−21, 6) | 0.160 |
| NMR LDL cholesterol (mg/dl) | 6.0 (−2, 22) | −4.0 (−25.5, 7) | 0.084 |
| Total HDL cholesterol (mg/dl) | 2.0 (−1, 16) | −6.0 (−10, −2) | 0.006 |
| Total VLDL and chylomicron particles (nmol/liter) | 0.2 (−0.6, 1.1) | −2.1 (−14.5, 8.4) | 0.345 |
| Large VLDL and chylomicron particles (nmol/liter) | 0.2 (−0.6, 1.1) | −0.3 (−1.0, 0.5) | 0.279 |
| Medium VLDL particles (nmol/liter) | 0.7 (−2.0, 6.3) | −3.8 (−9.2, 5.7) | 0.369 |
| Small VLDL particles (nmol/liter) | 0.1 (−6.6, 9.2) | 0.8 (−10.6, 7.2) | 0.549 |
| Total LDL particles (nmol/liter) | 90 (−14, 317) | −42 (−272, 75) | 0.058 |
| IDL particles (nmol/liter) | 23 (−14, 73) | −8 (−43, 3) | 0.040 |
| Large LDL particles (nmol/liter) | −39 (−76, 129) | 3 (−81, 11) | 0.890 |
| Total small LDL particles (nmol/liter) | 73 (−24, 179) | −14 (−208, 105) | 0.147 |
| Medium small LDL particles (nmol/liter) | 10 (−11, 18) | −6 (−37, 1) | 0.123 |
| Very small LDL particles (nmol/liter) | 63 (−15, 151) | −11 (−183, 89) | 0.170 |
| Total HDL particles (μmol/liter) | 1.7 (−1.3, 4.0) | −3.2 (−5.7, 0.3) | 0.022 |
| Large HDL particles (μmol/liter) | 0.5 (0.2, 2.6) | −1.0 (−2.7, −0.4) | 0.006 |
| Medium HDL particles (μmol/liter) | −0.6 (−1.4, 0.8) | −0.7 (−1.9, 1.2) | 0.782 |
| Small HDL particles (μmol/liter) | 1.2 (−0.8, 3.7) | −1.8 (−3.5, −0.1) | 0.062 |
P values in bold denote statistically significant results.