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. 2008 Dec 9;94(3):1042–1048. doi: 10.1210/jc.2008-1861

Table 3.

Associations of CASR with urinary Ca excretion in a cross-sectional study (P values)

SNP MAF HWE (P value) Ca excretion rate, log uCa (mg/h)
Population-based analysis (n = 106) Family-based analysis (n = 88)
rs6776158 0.46 0.05 0.95 0.26
rs1501900 0.09 0.88 0.12 0.62
rs937627 0.07 0.12 0.96 0.56
rs6438712 0.28 1.00 0.03A 0.0002A
rs4678172 0.29 1.00 0.02T 0.0007T
rs9874845 0.31 1.00 0.02A 0.0028A
rs4678059 0.12 0.32 <0.0001A 0.0001A
rs1965357 0.15 0.87 0.0007C 0.03C
rs937626 0.34 1.00 0.02G 0.002G
rs3749204 0.43 0.90 0.98 0.96
rs3749207 0.31 0.26 0.28 0.85
rs3804593 0.23 0.24 0.95 0.69
rs2279802 0.05 1.00 0.69 0.63
rs2270916 0.05 1.00 0.64 a
rs9740 0.20 0.82 0.74 0.39

The increased risk allele that associates with a lower urinary Ca is depicted as superscript when P ≤ 0.001 and MAF is higher than 0.10. Letters in superscript depict the nucleotides that are associated with a lower urinary excretion of Ca (A, Adenine; T, thymine). HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency; uCa, urinary Ca. 

a

Estimable size effect due to MAF was less than 0.05 and lack of variability.