Table 3.
Associations of CASR with urinary Ca excretion in a cross-sectional study (P values)
SNP | MAF | HWE (P value) | Ca excretion rate, log uCa (mg/h)
|
|
---|---|---|---|---|
Population-based analysis (n = 106) | Family-based analysis (n = 88) | |||
rs6776158 | 0.46 | 0.05 | 0.95 | 0.26 |
rs1501900 | 0.09 | 0.88 | 0.12 | 0.62 |
rs937627 | 0.07 | 0.12 | 0.96 | 0.56 |
rs6438712 | 0.28 | 1.00 | 0.03A | 0.0002A |
rs4678172 | 0.29 | 1.00 | 0.02T | 0.0007T |
rs9874845 | 0.31 | 1.00 | 0.02A | 0.0028A |
rs4678059 | 0.12 | 0.32 | <0.0001A | 0.0001A |
rs1965357 | 0.15 | 0.87 | 0.0007C | 0.03C |
rs937626 | 0.34 | 1.00 | 0.02G | 0.002G |
rs3749204 | 0.43 | 0.90 | 0.98 | 0.96 |
rs3749207 | 0.31 | 0.26 | 0.28 | 0.85 |
rs3804593 | 0.23 | 0.24 | 0.95 | 0.69 |
rs2279802 | 0.05 | 1.00 | 0.69 | 0.63 |
rs2270916 | 0.05 | 1.00 | 0.64 | a |
rs9740 | 0.20 | 0.82 | 0.74 | 0.39 |
The increased risk allele that associates with a lower urinary Ca is depicted as superscript when P ≤ 0.001 and MAF is higher than 0.10. Letters in superscript depict the nucleotides that are associated with a lower urinary excretion of Ca (A, Adenine; T, thymine). HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency; uCa, urinary Ca.
Estimable size effect due to MAF was less than 0.05 and lack of variability.