Table 5.
Associations of the SNP rs2470152 with BMD in men
| AA | AG | GG | Per G allele effect size in sd of BMD (sem) | P1 | P2 | |
|---|---|---|---|---|---|---|
| Lumbar spine BMD | ||||||
| GOOD (g/cm2) | n = 241 | n = 517 | n = 288 | |||
| 1.23 ± 0.14 | 1.23 ± 0.13 | 1.26 ± 0.13 | 0.09 (0.04) | 0.03 | 0.03 | |
| MrOS Sweden (g/cm2) | n = 610 | n = 1366 | n = 816 | |||
| 1.17 ± 0.21 | 1.17 ± 0.20 | 1.19 ± 0.13 | 0.05 (0.03) | 0.15 | 0.07 | |
| Combined | 0.06 (0.02) | 0.008 | ||||
| Femoral neck BMD | ||||||
| GOOD (g/cm2) | n = 241 | n = 517 | n = 288 | |||
| 1.16 ± 0.14 | 1.16 ± 0.14 | 1.18 ± 0.15 | 0.07 (0.04) | 0.17 | 0.09 | |
| MrOS Sweden (g/cm2) | n = 603 | n = 1320 | n = 787 | |||
| 0.85 ± 0.14 | 0.85 ± 0.14 | 0.86 ± 0.13 | 0.02 (0.03) | 0.67 | 0.43 | |
| Combined | 0.04 (0.02) | 0.12 |
The predictive role of rs2470152 for BMD of the lumbar spine and the femoral neck evaluated in young adult (GOOD) and elderly (MrOS Sweden) men. n, Number of subjects with both successful genotyping and available BMD. BMD was adjusted for age, BMI, smoking, and physical activity. P1, P value from ANOVA. P2 values are calculated using linear regression under an additive model, corrected for study cohort in the combined (GOOD + MrOS Sweden) analyses. Z-scored BMD values were used in the combined linear regression analyses. No significant interaction effect was seen between cohort and rs2470152 genotype. Effect size (regression coefficient) and se values are expressed in sd units.