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The compound IF Scl-70 pattern is reproduced by affinity-purified antibodies to DNA topo I. IIF on HEp-2 cells (Bion) with human monospecific anti-DNA topo I serum diluted to the ratio 1 : 80 (A), western blot-based affinity-purified anti-DNA topo I antibody preparation diluted 1 : 5 (B and inset) and protein A–Sepharose-based affinity-purified anti-DNA topo I antibody preparation diluted 1 : 100 (C). Scale bars = 7.5 µm.
