Fig. 6.

Effect of pair-feeding on glucose-stimulated hypothalamic insulin signaling. Effects of dietary fat content on phosphoserine PKB (A) with 15-min vehicle (open bars) or glucose (3 g/kg lean mass; solid bars) treatment administered intraperitonally. Pair-feeding also resulted in increased phosphorylation of IKKβ (B) and decreased total IκBα (C). The relationship between phosphorylated PKB and peak plasma insulin levels was compared among groups in mediobasal hypothalamus (D), liver (E), and muscle (F). *P < 0.05.