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Effects of central IKK inhibitor on food intake, inflammation, and insulin signaling. Cumulative food intake measurements over a 24-h period after intracerebroventricular injection of vehicle or PS1145 (IKK inhibitor) in low-fat and high-fat fed animals are shown (A). PS1145 treatment results in increased total IκBα levels (B) and modestly increased insulin stimulated phosphoserine PKB (C). #P < 0.05; *P < 0.01.
