Table 3.

Summary of the 2 networks and their relevant functions derived from the 21 published ALI genes

Published ALI Genes/Molecules in Network	Other Related Genes/Molecules in Network	Associated Diseases and Disorders (Top 5)	Associated Molecular and Cellular Functions (Top 5)
Network 1 (12 genes): ACE, IL6, IL8, IL10, TNF, LTA, NFKB1, NFKBIA, SFTPB, VEGFA, PLAU, F5	Ap1, CSF3, DBT, DEFB103A, DEFB4 (includes EG:1673), F2, Factor 10-Factor5, Histone h3, IκB-NfκB1-RelA, Iκb-Rela-Nfκb1-Pkac, IL1/IL6/TNF, LYL1, MICA, NFκB, NfκB-Nfκbia, NKIRAS1, REL/RELA/RELB, RNA polymerase II, SERPINB6, STAT3, TAL2, TNFSF4, UMOD	1. Organismal injury and abnormalities;	1. Cellular movement;
Network 2 (9 genes): FTL, HMOX2, MBL2, MIF, MYLK, PBEF1 (NAMPT), NFE2L2, SOD3, NQO1	C4A, C6ORF108, CDCA7L, CYP2J2, DHX8, ENC1, GAS1, GSS, HNF4A, Ho, IFITM2, JUN, MINA, MYC, NFE2L3, NQO, PERP (includes EG:64065), PLEKHO1, PPCS, RPL41, SLC25A19, SMARCA4, STARD10, SUCLA2, TPP2, WRNIP1	2. Immunological disease;	2. Cell death;
				3. Hematological disease;	3. Lipid metabolism;
				4. Respiratory disease;	4. Small molecule biochemistry;
				5. Inflammatory disease	5. Cell-to-cell signaling and interaction