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Relation between lubiprostone concentration and tracheal SCC responses in the sheep. The effect of the cumulative addition of lubiprostone from 2 to 200 nM on SCC is shown in A. The values at the beginning and end of the trace show the mean values of SCC for 4 ventral epithelia. Normalized values ± SE for the change in SCC with lubiprostone concentration are shown on an arithmetic scale in B and a logarithmic scale in C.
