Fig. 4.

Lubiprostone (lubi) responses are greater in ventral (V) than dorsal (D) sheep tracheal epithelia. Shown is a comparison of lubiprostone responses in matched pairs of dorsal and ventral epithelia from sheep trachea. In each tissue, responses to 200 nM lubiprostone and 10 μM amiloride, both applied apically, are shown. Lubiprostone responses in all 6 tissues are summarized in D, where open columns represent dorsal and filled columns ventral epithelia for measurements made at 2 h (A), 5 h (B), and 8 h (C) postculling (pc). The final pair of columns gives the mean values and standard errors for epithelia from both locations.