Fig. 4.
Effect of MK801 on early proximal flow rate and Jprox when added to free flowing early S1 segment at 5 nl/min. Three collections were done in each nephron: baseline, drug perfusion (MK801 or placebo), and recovery. MK801 decreased SNGFR so adding it at 5 nl/min had no effect on early proximal flow. Therefore, we can conclude that MK801 suppresses Jprox independent of the early proximal flow rate. Right: only the first 2 collections. *P < 0.008 for effect of MK801 on Jprox by repeated-measures ANOVA.