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Photomicrographs of representative kidneys from sibling littermate +/+ (A, C) and Br/+ (B, D) mice. Note the larger size of the +/+ kidney compared with the smaller, cystic Br/+ kidney. Normal glomeruli (C, arrowheads) display cuboidal epithelia in +/+ animals compared with the 3H1 Br/+ kidney with enlarged glomeruli (D, arrowheads), enlarged tubules (t), and increased cellularity between nephrons (*). Bar = 3.0 mm in A and B; 200 μm in C and D.
