Fig. 1.

A: Plasma total cholesterol levels in WT (white bars), control SR-BI KO mice (hatched bars), and SR-BI KO mice expressing human CETP (SR-BI KO/CETP Tg; black bars). B) The adrenal uptake of HDL-cholesteryl ether (CEt) in WT (white bars), control SR-BI KO mice (hatched bars), and SR-BI KO mice expressing human CETP (SR-BI KO/CETP Tg; black bars). Mice were injected intravenously with [³H]CEt-HDL, and after 24 h the amount of radioactivity in the adrenals was determined. Values are expressed as percentage of the injected dose per gram tissue (%ID/g) and are means ± SEM (n = 3). C: Distribution of [³H]CEt over the different lipoprotein fractions generated from pooled plasma of three mice at 8 h after injection of the [³H]CEt-HDL in control SR-BI KO mice (hatched bars) and SR-BI KO mice expressing human CETP (SR-BI KO/CETP Tg; black bars). * P < 0.05, ** P < 0.01, and *** P < 0.001 (one-way ANOVA).