Fig. 6.
TP-NADPH oxidase regulates TP expression in mASMC. A, B: Wild-type mASMC were pretreated with vehicle or apocynin (100 μM, 30 min) prior to IBOP (1 μM, 24 h). C, D: p47−/− mASMC were treated with or without IBOP (1 μM. 24 h). Cell lysates were resolved by SDS-PAGE and TP detected using an anti-TP antibody. A, C: Western blots are representative of three independent experiments. B, D: Mean fold over basal expression ± SEM from densitometric analysis normalized to β-actin (n = 3). ns, nonspecific. * P < 0.05 and *** P < 0.001 w.r.t. control unless otherwise indicated.