Fig. 3.

Requirement of SHP for WAY-362450 inhibition of dyslipidemia and aortic atherosclerosis. SHP^−/− mice in a 129 strain background (18) were backcrossed to C57BL/6J mice for four generations using speed congenics to maximize the C57BL/6J background at each cross. The resulting mice were then bred to C57BL/6J LDLR^−/− mice to generate LDLR^−/−SHP^−/− mice. Similarly, SHP^−/− mice were backcrossed to C57BL/6J apoE^−/− mice for six generations to generate apoE^−/−SHP^−/− mice. The LDLR^−/−SHP^−/− and apoE^−/−SHP^−/− were analyzed as described in Fig. 2.