TABLE A2.

Mitochondria reactions and stoichiometry

Mitochondria Reactions	Stochiometry
1. Aspartate aminotransferase	OAA+GLU → Asp+AKG
2. Pyruvate dehydrogenase	PYR+CoA+NAD+ → ACoA+NADH + CO2
3. Pyruvate carboxylase*	PYR+ATP+CO2 → OAA+ADP+Pi
4. Malic enzyme	PYR+CO2+NADH ⇋ MAL+NAD+
5. Citrate synthase	ACoA+OAA → CIT+CoA
6. Isocitrate dehydrogenase	CIT+NAD+ → AKG+NADH+CO2
7. Alpha-ketoglutarate dehydrogenase	AKG+CoA+NAD+ → SCoA+NADH+CO2
8. Succinyl-CoA synthase	SCoA+ADP+Pi → SUC+CoA+ATP
9. Succinate dehydrogenase	SUC+NAD+ → FUM+NADH
10. Fumarase	FUM → MAL
11. Malate dehydrogenase	MAL+NAD+ → OAA+NADH
12. Glutamate dehydrogenase	AKG+NADH ⇋ GLU+NAD+
13. Glutamate decarboxylase†	GLU → GABA+CO2
14. GABA transaminase†	GABA+AKG → SSA+GLU
15. Succinic semialdehyde dehydrogenase†	SSA+NAD+ → SUC+NADH
16. Oxidative phosphorylation	O2+2NADH+6ADP+6Pi → 2H2O+2NAD++6ATP

Biochemical reactions in the mitochondria of astrocyte and neuron.

^*, the reaction takes place only in the astrocytes;

^†, the corresponding reaction occurs only in neurons.