TABLE A3.
Estimated reaction fluxes and transport rates
| Activity | Low |
High | ||
|---|---|---|---|---|
| Astrocyte | Neuron | Astrocyte | Neuron | |
| Jb→c,GLC | 0.22 ± 0.06 | 0.14 ± 0.06 | 0.36 ± 0.04 | 0.08 ± 0.03 |
| ΦBPG→PYR | 0.44 ± 0.12 | 0.28 ± 0.11 | 0.72 ± 0.07 | 0.16 ± 0.07 |
| ΦPYR⇋ LAC | 0.24 ± 0.19 | −0.12 ± 0.19 | 0.70 ± 0.07 | −0.58 ± 0.07 |
| ΦATP→ADP+Pi | 3.92 ± 1.68 |
2.13 ± 1.56 | 0.47 ± 0.21 | 0.15 ± 0.15 |
| Jb⇋c,LAC | −0.24 ± 0.19 |
0.12 ± 0.19 | −0.70 ± 0.07 | 0.59 ± 0.07 |
| ΦAap→OAA | 0.21 ± 0.10 | 0.40 ± 0.10 | 0.02 ± 0.01 | 0.74 ± 0.01 |
| ΦOAA→MAL | 0.21 ± 0.10 | 0.40 ± 0.10 | 0.02 ± 0.01 | 0.74 ± 0.01 |
| ΦOAA→Asp | 0.21 ± 0.10 | 0.40 ± 0.10 | 0.02 ± 0.01 | 0.74 ± 0.01 |
| Jc⇋m,MAL,AKG | 0.21 ± 0.10 | 0.40 ± 0.10 | 0.02 ± 0.01 | 0.74 ± 0.01 |
| Jc⇋m,Asp,GI,U | 0.21 ± 0.10 |
0.40 ± 0.10 | 0.02 ± 0.01 | 0.74 ± 0.01 |
| Jc→mPYR | 0.21 ± 0.10 | 0.40 ± 0.10 | 0.02 ± 0.01 | 0.74 ± 0.01 |
| Jc→m,ADP | 3.68 ± 1.72 | 7.40 ± 1.75 | 0.30 ± 0.19 | 13.93 ± 0.21 |
| Jc→m,Pi | 3.68 ± 1.72 | 7.40 ± 1.75 | 0.30 ± 0.19 | 13.93 ± 0.21 |
| Jm→c,ATP | 3.68 ± 1.72 |
7.40 ± 1.75 | 0.30 ± 0.19 | 13.93 ± 0.21 |
| ΦGLU→Gln | 0.22 ± 0.06 | 0.54 ± 0.01 | ||
| ΦGln→GLU | 0.22 ± 0.06 | 0.54 ± 0.01 | ||
| JN→A,GLU | 0.22 ± 0.06 | 0.54 ± 0.01 | ||
| JA→N,Gln | 0.22 ± 0.06 | 0.54 ± 0.01 | ||
Posterior mean values ± SD predicted by the model for the biochemical reactions and transport fluxes identifying the interaction between astrocyte and glutamatergic neuron at different neural activation levels (Low and High). The negative sign means that the overall reaction is toward the substrate or the compartment on the left side. The units are μmol·gtissue−1·min−1. The values of the means ± SD below a threshold of 10−3 are considered as zeros and denoted by ∼0.