FIG. 3.

Changes in the properties of individual mEPSCs after AP-5. A and C: the amplitudes and rise times of mEPSCs were not different before and after application of (n = 10). This suggests that a fast non-NMDA component dominates these 2 parameters at −67 mV (1.25 mM Mg²⁺). B and D: absolute charge transfer during a mEPSC and mEPSC decay times were significantly reduced in the presence of AP-5 (both, ∼20% difference). E: cumulative distributions of charge transfer by mEPSCs before and after application of AP-5 at −67-mV holding potential. This graph shows that the AP-5 induced reduction in total charge transfer by individual mEPSCs was homogenously distributed across all mEPSC sizes. F and G: cumulative distributions of rise times and decay times of mEPSCs before and after application of AP-5 at −67-mV holding potential. These graphs show that the AP-5 application had a minimal effect on the distribution of rise times, whereas it significantly decreased the decay times of individual mEPSCs. In both cases, however, mEPSCs were affected in a homogenous manner.