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. 2009 Mar 4;101(5):2539–2549. doi: 10.1152/jn.91282.2008

FIG. 5.

FIG. 5.

Selectivity of PKA and CaMKII antagonists and effects on p-CREB. A: bath application of Rp-cAMPs during 2 sessions of paired stimulation significantly reduced the conditioning-related increase in PKA phosphorylation to pseudoconditioned levels, whereas AIP had no significant effect. B: application of AIP for 2 sessions suppressed phosphorylation of CaMKII, whereas Rp-cAMPs failed to have a significant effect. C: application of Rp-cAMPs for 2 pairing sessions significantly attenuated phosphorylation of CREB compared with conditioning. Coapplication of Rp-cAMPs with the general CaMKII antagonist KN-62 for 2 sessions completely inhibited CREB phosphorylation to levels similar to pseudoconditioning. *Indicates significant differences from Ps2; # indicates significant differences from C2.