Figure 4.

Western blot analysis of HO-1 protein expression in MCT-PH (A) and CH-PH (B) rat lung. Densitometric quantification revealed a significant increase in expression of HO-1 protein in the lungs of rats that received simvastatin and SnPP treatment. Densitometric units were normalized to β-actin and then divided by N group results. (N = normal control, NS = normal + simvastatin treatment, M = monocrotaline treatment, MS = monocrotaline + simvastatin treatment, MSP = monocrotaline + simvastatin + SnPP treatment, MP = monocrotaline + SnPP treatment, H = chronic hypoxia, HS = chronic hypoxia + simvastatin treatment, HSP = chronic hypoxia + simvastatin + SnPP treatment, HP = chronic hypoxia + SnPP treatment).