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Immunohistochemical staining of the distribution of HO-1 in rat lung. Simvastatin treatment led to marked HO-1 immunoreactivity around pulmonary vascular sites. (A) normal control, (B) MCT-PH rats, (C) CH-PH rats, (D) normal rats treated with simvastatin, (E) simvastatin treated, MCT-PH rats, (F) simvastatin treated, CH-PH rats. Magnification: 400×. Bars represent 20 μm.
