Table 4.

Summary of the total number of sites, substitutions and substitutions per site at synonymous and noncoding regions, substitutions involving CpGs, relative proportion of substitutions involving CpG dinucleotides and the number of substitutions per site without the influence of CpG dinucleotides

	Total sites	Total substitutions	Substitutions per site	Substitutions involving CpGs	Proportion of substitutions involving CpGs	Substitutions per site sans CpG
Synonymous	286,995	7,394	0.026	2,262	0.31	0.018
Noncoding	3,767,771	68,602	0.018	8,212	0.12	0.016

Chi-Square comparing the relative proportion of substitutions involving CpG dinucleotides at synonymous and noncoding sites χ² = 1,300, p < 0.001 and substitutions that did not involve CpG dinucleotides χ² = 55.7, p < 0.001