Table 4.
Adjusteda risk of adverse outcomes for surrogates of a decreasing rate of creatinine generation among an age-stratified sample of 664 Rochester, Minnesota residents
| Urinary creatinine per - s.d. |
Muscle mass per - s.d. |
Age per s.d. (20 years) |
Sex (female) |
|
|---|---|---|---|---|
| Adverse outcomes | Hazard ratios (95% confidence interval) | |||
| Mortality | 1.6 (1.2, 2.0) | 0.9 (0.6, 1.3) | 5.5 (4.1, 7.5) | 0.5 (0.3, 1.0) |
| Cardiovascular disease | 1.2 (1.0, 1.6) | 0.7 (0.5, 1.0) | 3.6 (2.8, 4.6) | 1.1 (0.6, 2.2) |
| Coronary artery disease | 0.9 (0.7, 1.2) | 0.7 (0.4, 1.1) | 3.5 (2.6, 4.8) | 1.1 (0.5, 2.2) |
| Heart failure | 1.4 (1.0, 2.0) | 0.5 (0.3, 0.9) | 5.7 (3.8, 8.6) | 1.3 (0.5, 3.1) |
| Stroke | 1.2 (0.8, 1.8) | 1.1 (0.7, 2.0) | 2.9 (2.1, 4.2) | 0.8 (0.3, 2.1) |
| Peripheral vascular disease | 1.2 (0.9, 1.6) | 1.0 (0.6, 1.6) | 2.8 (2.0, 3.9) | 0.5 (0.2, 1.1) |
a
Adjusted for all other surrogates; results similar with further adjustment for dietary protein intake and reciprocal serum creatinine.