TABLE 2.
Susceptibilities of 260 VVC isolates and quality control strains determined by the CLSI M27-A2 and EUCAST broth microdilution methods
| Candida isolate (no.) or QC straina | Method | Itraconazole
|
Fenticonazole
|
Fluconazole
|
Ketoconazole
|
||||
|---|---|---|---|---|---|---|---|---|---|
| MIC50 range (μg/ml) | GMb (μg/ml) | MIC50 range (μg/ml) | GM (μg/ml) | MIC50 range (μg/ml) | GM (μg/ml) | MIC50 range (μg/ml) | GM (μg/ml) | ||
| C. albicans (249) | CLSI | 0.03-0.5 | 0.07 | 0.03-0.5 | 0.14 | 0.12-16 | 1.86 | 0.12-4.0 | 0.78 |
| EUCAST | 0.03-0.5 | 0.06 | 0.03-0.25 | 0.10 | 0.12-32 | 1.84 | 0.12-4.0 | 0.54 | |
| C. glabrata (11) | CLSI | 0.03-0.5 | 0.10 | 0.03-1 | 0.34 | 2.0-≥64 | 7.51 | 0.5-4.0 | 1.86 |
| EUCAST | 0.03-0.5 | 0.10 | 0.03-0.5 | 0.28 | 2.0-≥64 | 7.51 | 2.0-8.0 | 2.13 | |
| C. parapsilosis ATCC 22019 | CLSI | 0.06-0.25 | 0.14 | 0.03-1c | 0.16 | 2-8 | 3.73 | 0.12-0.25 | 0.17 |
| EUCAST | 0.06-0.12 | 0.09 | 0.03-0.25d | 0.13 | 0.5-4 | 2.14 | 0.12-0.5 | 0.21 | |
| C. krusei ATCC 6258 | CLSI | 0.12-0.5 | 0.10 | 0.06-2e | 0.23 | 16-64 | 45.25 | 0.25-0.5 | 0.33 |
| EUCAST | 0.03-0.12 | 0.08 | 0.06-1f | 0.20 | 32-64 | 45.25 | 0.12-1 | 0.26 | |
a
Results were obtained for 20 independent tests. QC, quality control.
b
GM, geometric mean.
c
One of 20 test results (MIC, 1 μg/ml) was out of the observed range of 0.03 to 0.5 μg/ml.
d
No test result was out of range.
e
One of 20 test results (MIC, 2 μg/ml) was out of the observed range of 0.06 to 0.5 μg/ml.
f
One of 20 test results (MIC, 1 μg/ml) was out of the observed range of 0.06 to 0.25 μg/ml.