TABLE 1.
Comparison of patients treated with CI and II for IE caused by MSSA
| Characteristic | Valuea for patients treated with:
|
P value | ||
|---|---|---|---|---|
| CI or II (overall) | CI (n = 78) | II (n = 29) | ||
| Median age, yr (range) | 41 (18-85) | 40 (18-85) | 45 (19-84) | 0.1 |
| Male gender | 77 (72) | 58 (74) | 19 (66) | 0.4 |
| Race or ethnic group | ||||
| White | 27 (25) | 16 (21) | 11 (38) | 0.07 |
| Black | 3 (3) | 1 (1) | 2 (7) | 0.2 |
| Hispanic | 76 (71) | 60 (77) | 16 (55) | 0.03 |
| Asian | 1 (0.9) | 1 (1) | 0 (0) | 1 |
| Median body mass index (range)b | 24 (11-72) | 24 (11-72) | 24 (19-32) | 0.8 |
| Median creatinine clearance (range)c | 85 (15-262) | 85 (15-248) | 84 (19-262) | 0.8 |
| Risk factors/comorbidities | ||||
| CABGd | 4 (4) | 2 (3) | 2 (7) | 0.3 |
| Hemodialysis dependent | 7 (7) | 7 (9) | 0 (0) | 0.09 |
| Diabetes mellitus | 25 (23) | 19 (24) | 6 (21) | 0.8 |
| IDU | 86 (80) | 63 (81) | 23 (79) | 1 |
| Preexisting mechanical valve | 8 (8) | 6 (8) | 2 (7) | 1 |
| History of infective endocarditis | 20 (19) | 14 (18) | 6 (21) | 0.8 |
| HIVe positive | 8 (8) | 4 (5) | 4 (14) | 0.2 |
| Diagnostic criteria | ||||
| Two major criteria | 85 (79) | 62 (79) | 23 (79) | 1 |
| One major criterion | 22 (21) | 16 (21) | 6 (21) | 1 |
| Presenting signs/symptoms | ||||
| Fever/temp of >38°Cf | 91 (85) | 65 (83) | 26 (90) | 0.5 |
| Chills | 60 (56) | 48 (62) | 12 (41) | 0.06 |
| Serum creatinine (mg/dl) | 1.3 | 1.3 | 1.2 | 0.9 |
| WBC count (×1,000 cells per μl) | 14.5 | 15 | 13 | 0.1 |
| Janeway's lesions | 8 (8) | 7 (9) | 1 (3) | 0.3 |
| Septic emboli | 31 (29) | 25 (32) | 6 (21) | 0.2 |
| Pulmonary emboli | 59 (55) | 43 (55) | 16 (55) | 1 |
| Osler's nodes | 8 (8) | 7 (9) | 1 (3) | 0.3 |
| Splinter hemorrhage | 7 (7) | 5 (6) | 2 (7) | 0.9 |
| Poor dentition | 35 (33) | 26 (33) | 9 (31) | 0.8 |
a
Values are numbers (percentages) unless indicated otherwise.
b
The body mass index was calculated as follows: weight (kg)/height (m2).
c
Creatinine clearance was determined by the Cockcroft-Gault method.
d
CABG, coronary artery bypass graft.
e
HIV, human immunodeficiency virus.
f
The mean temperatures were 38.3°C for all patients treated with CI or II, 38.4°C for the patients treated with CI, and 38.3°C for the patients treated with II (P = 0.6).