TABLE 4.

Differentially expressed genes in strains exhibiting reduced Var susceptibility

Locus	Gene	Predicted function(s) and description	Change (fold) in transcript amt in mutant
			VarA	VarE	VarF	VarG
spr0030	NAa	Unknown		0.32
spr0446	hsdS	Type I restriction modification enzyme specificity protein		3.76
spr0448	hsdS	Type I restriction modification enzyme specificity protein	0.29
spr0466	blpB	Transport protein, C-terminal fragment	3.18
spr0467	blpB	Transport protein, N-terminal fragment	3.61
spr0468	blpA	Bacteriocin transport-processing ATP-binding protein	3.70
spr0639	copY	Copper transport transcriptional repressor	5.24	3.15	3.99
spr0812	NA	ABC transporter ATP-binding protein				8.90
spr0881	coiA	Competence protein, possible transcription factor		0.32
spr1548	NA	Unknown	0.30
spr1549	NA	Unknown	0.31
spr1628	pilD	Type IV prepilin peptidase		0.26
spr1758	cinA	Competence damage-inducible protein		0.29
spr1764	NA	Unknown	6.67
spr1765	NA	Unknown	4.15		4.08
spr1766	NA	Unknown	7.11	7.50	8.40
spr1767	cylM	Cytolysin subunit modifying protein	3.47	4.49	5.87
spr1768	NA	Unknown	3.94	6.32	3.38
spr1769	NA	Unknown	3.50	5.24
spr1770	cylB	Toxin secretion ABC transporter ATP-binding-permease protein	4.73	7.17	5.46
spr1773	NA	ABC transporter ATP-binding protein	3.22	3.94	3.30
spr1859	NA	Competence protein		0.28
spr1863	cglB	Competence protein, type II secretion system protein		0.24
spr1864	cglA	Competence protein, type II secretion system ATPase		0.24

^aNA, not available.