TABLE 1.

Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms in 23 Plasmodium falciparum strains^a

Strain	Origin	QN IC50 (nM)	Amino acid encoded by Pfcrt codon:								Amino acid encoded by Pfmdr1 codon:					Amino acid encoded by Pfmrp codon:		Pfnhe-1 microsatellite ms4760b
			74	75	76	220	271	326	356	371	86	184	1034	1042	1246	191	437	No. of DNNND repeats	No. of DDNHNDNHNN repeats	Mutation	Profile
IMT 9881	Niger	57	M	N	K	A	Q	N	I	R	N	Y	S	N	D	H	S	3	2	N	9
IMT 10354	Comoros	58	I	E	T	S	Q	N	I	I	Y	F	S	N	Y	H	S	1	3	N	12
D6	Sierra Leone	62	M	N	K	A	Q	N	I	R	N	Y	S	N	D	H	S	1	2	N	3
IMT 16332	Congo	83	I	E	T	S	E	N	T	I	Y	Y	S	N	D	H	S	1	2	N	3
3D7	Africa	128	M	N	K	A	Q	N	I	R	N	Y	S	N	D	H	S	1	2	K	2
IMT 8425	Senegal	148	M	N	K	A	Q	N	I	R	N	Y	S	N	D	H	S	1	2	K	2
IMT 16116	Congo	204	I	E	T	S	E	N	I	I	Y	F	S	N	D	H	S	2	2	N	18
IMT 10500	Comoros	210	M	N	K	A	E	N	I	R	N	Y	S	N	D	H	S	1	2	K	2
IMT 10336	Comoros	271	M	N	K	A	E	N	I	R	N	Y	S	N	D	H	S	1	2	N	3
FCR3	The Gambia	334	I	E	T	S	E	S	I	I	Y	Y	S	N	D	Y	A	2	1	N	6
IMT 31	Senegal	371	M	N	K	A	Q	N	I	R	N	Y	S	N	D	H	S	1	2	N	3
IMT Vol	Djibouti	421	I	E	T	S	E	S	I	I	Y	Y	S	N	D	Y	A	2	1	N	6
IMT 6311	Senegal	453	I	E	T	S	E	N	T	I	Y	F	S	N	D	H	S	3	1	N	7
IMT Bres	Brazil	500	I	E	T	S	E	S	I	I	Y	Y	S	N	D	Y	A	2	1	N	6
IMT L1	Niger	575	I	E	T	S	E	N	I	I	Y	Y	S	N	D	Y	A	2	1	N	6
FCM29	Cameroon	580	I	E	T	S	E	S	I	I	Y	Y	S	N	D	Y	A	3	1	N	7
IMT K2	Cambodia	599	I	E	T	S	V	S	T	I	N	F	C	D	D	Y	A	3	1	N	7
IMT A4	Thailand	605	I	E	T	S	E	S	I	I	N	F	C	D	Y	H	S	3	1	N	7
PA	Uganda	625	I	E	T	S	E	S	I	I	Y	Y	S	N	D	Y	A	2	1	N	6
W2	Indochina	686	I	E	T	S	E	S	T	I	Y	Y	S	N	D	Y	A	2	2	N	1
IMT K4	Cambodia	1,034	I	E	T	S	E	S	T	I	N	Y	C	D	D	Y	A	3	1	N	7
IMT 9996	Comoros	1,039	M	N	K	A	Q	N	I	R	N	Y	S	N	D	H	S	2	1	N	6
IMT K14	Cambodia	1,310	I	E	T	S	E	S	T	I	N	F	C	D	Y	Y	A	3	1	N	7

^aBoldface indicates point mutations.

^bPolymorphism types are detailed in Fig. 1.