TABLE 2.

Association of in vitro QN response (IC₅₀) and polymorphisms on the Pfnhe-1, Pfcrt, Pfmdr1, and Pfmrp genes of 23 strains of Plasmodium falciparum^a

Genotype	P value	Significanceb
Pfnhe-1 ms4760 profiles	0.0021	S
Pfnhe-1, no. of DNNND repeats	0.0007	S
Pfnhe-1, no. of NHNDNHNNDDD repeats	0.0020	S
Mutation in codon 74 of Pfcrt gene	0.0454	NS
Mutation in codon 75 of Pfcrt gene	0.0454	NS
Mutation in codon 76 of Pfcrt gene	0.0454	NS
Mutation in codon 220 of Pfcrt gene	0.0454	NS
Mutation in codon 271 of Pfcrt gene	0.0688	NS
Mutation in codon 326 of Pfcrt gene	0.0019	S
Mutation in codon 356 of Pfcrt gene	0.0687	NS
Mutation in codon 371 of Pfcrt gene	0.0454	NS
Mutation in codon 86 of Pfmdr1 gene	1.0000	NS
Mutation in codon 184 of Pfmdr1 gene	0.5754	NS
Mutation in codon 1034 of Pfmdr1 gene	0.0119	NS
Mutation in codon 1042 of Pfmdr1 gene	0.0119	NS
Mutation in codon 1246 of Pfmdr1 gene	0.5228	NS
Mutation in codon 191 of Pfmrp gene	0.0036	NS
Mutation in codon 437 of Pfmrp gene	0.0036	NS

^aDetermined by Mann-Whitney U test or Kruskal-Wallis test. The variable was the QN IC₅₀. The significance cutoff was 0.0028 (0.05/18, 18 tests, Bonferroni correction).

^bS, significant; NS, nonsignificant.