TABLE 3.

Intracellular PK parameters of 3TC-TP and TFV-DP in men and women in the presence of lopinavir-ritonavir or nevirapine

Drug	No. of patients	AUC0-4		Ctrough
		Mean (fmol·h/106 cells)	CVa (%)	Mean (fmol/106 cells)	CV (%)
3TC-TP
With LPV/r
In women	2	86,710	67	15,310	36
In men	5	43,160	49	9,112	12
GMRb		1.91		1.64
With NVP
In women	3	61,520	79	14,010	86
In men	5	38,330	43	8,185	32
GMR		1.40		1.42
P valuec		0.084		0.082
TFV-DP
With LPV/r
In women	4	1,745	78	315	35
In men	10	921.2	45	233.1	54
GMR	1.72			1.45
With NVP
In women	3	829.3	30	241.5	28
In men	10	590.8	27	137.7	36
GMR		1.41		1.84
P valuec		0.045		0.039

^aCV, coefficient of variation.

^bGMR, ratio of the GM for women to the GM for men.

^cBy two-way analysis of variance.