FIG. 3.

Effects of treatment with amantadine, oseltamivir, and ribavirin, used alone or in combination, on lung virus titers determined 72 h after influenza A/Duck/MN/1525/81 (H5N1) amantadine-sensitive virus infection of mice. Oral treatments were given twice a day starting 4 h before virus exposure, with the last treatment administered 4 h prior to sacrifice of the mice. Data are mean values ± standard deviations using lungs from five mice per group. A, amantadine plus oseltamivir; B, amantadine plus ribavirin; C and D, oseltamivir plus ribavirin. Values are shown as mg/kg/day.