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Therapeutic efficacy of AMB and VOR in transiently neutropenic rats with IPA. AMB was administered intravenously once daily at 1 mg/kg/day. VOR was administered i.p. at 12-h intervals according to the human pharmacokinetic equivalent dosage schedule. Treatment was started either 16, 24, 48, or 72 h after fungal inoculation and continued for 10 days. P values were determined with the log rank test by comparing the different dosing schedules.
