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Therapeutic efficacy of VOR and ANI in transiently neutropenic rats with IPA. VOR was administered i.p. at 12-h intervals according to the human pharmacokinetic equivalent dosage schedule for 10 days. ANI was administered s.c. once daily according to the human pharmacokinetic equivalent dosage schedule for either 3 or 10 days. Treatment was started 72 h after fungal inoculation. P values were determined with the log rank test by comparing the different dosing schedules.
