TABLE 1.

Human pharmacokinetic equivalent dosage schedule of VOR in rats^a

Time (h) after first injection	VOR dose (mg/kg, q12h)	AUC12 (μg·h/ml)	% of the human target AUC12
0-12	7.5	37.2	124
12-24	7.5	38.4	128
24-36	10.0	36.6	122
36-48	10.0	27.6	92
48-60	12.5	30.0	100
60-72	12.5	26.4	88
72-84	15.0	31.5	105
84-96	15.0	29.4	98
96-108	17.5	31.8	106
108-120	17.5	30.9	103
120-132	17.5	30.6	102
132-144	17.5	30.3	101
144-156	17.5	33.0	113
156-168	17.5	33.3	111
168-180	17.5	33.0	110
180-192	17.5	33.0	110
192-204	17.5	33.0	110
204-216	17.5	33.0	110
216-228	17.5	33.0	110
228-240	17.5	32.7	109
240-252	0	32.7	109

^aDoses were administered at 12-h intervals (q12h) as indicated. The AUC₁₂ for VOR was calculated on the basis of the population pharmacokinetic parameters given in Table 2. The percentage of the human target was obtained by dividing the AUC₁₂ by the human target value (29.5 μg·h/ml) × 100.