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Population pharmacokinetic parameters of VOR in ratsa
| Parameter | Mean | Between-rat variability (%) |
|---|---|---|
| k12 (h−1) | 7.8 | |
| V (ml) | 310 | 15 |
| Km (μg/ml) | 5.6 | |
| Vmax (μg/h) | 180 | 103 |
| kenz (h−1) | 0.076 | 223 |
| IC50 (μg/ml) | 0.045 | |
| Residual variability | ||
| Additive error (μg/ml) | 0.02 | |
| Proportional error (%) | 28 |
Standard errors of the estimates were <42%.
