TABLE 3.

Population pharmacokinetic parameters of ANI in rats^a

Parameter	Mean	Between-rat variability (%)
k12 (h−1)	0.089
V, day 0 and days 3 to 9 (ml)	455	28
V, day 1 (ml)	118
V, day 2 (ml)	236
CL, day 0 and days 3 to 9 (ml/h)	7.6	8
CL, day 1 (ml/h)	10.7
CL, day 2 (ml/h)	12.2
Residual variability
Additive error (μg/ml)	0.30
Proportional error (%)	20

^aStandard errors of the estimates were <36%.