TABLE 4.
Human pharmacokinetic equivalent dosage schedule of ANI in ratsa
| Time (h) after first injection | ANI dose (mg/kg, q24h) | AUC24 (μg·h/ml) | % of the human target AUC24 (%) |
|---|---|---|---|
| 0-24 | 20 | 77.2 | 64 |
| 24-48 | 5 | 197.0 | 164 |
| 48-72 | 5 | 125.1 | 104 |
| 72-96 | 5 | 114.5 | 95 |
| 96-120 | 5 | ND | ND |
| 120-144 | 5 | ND | ND |
| 144-168 | 5 | 114.5 | 95 |
| 168-192 | 5 | ND | ND |
| 192-216 | 5 | ND | ND |
| 216-240 | 5 | 150.2 | 125 |
a
Doses were administered at 24-h intervals as indicated. The AUC24 for ANI was calculated on the basis of the population pharmacokinetic parameters given in Table 3. The percentage of the human target was obtained by dividing the AUC24 by the human target value (120.3 μg·h/ml) × 100. ND, not done.