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Substrate profiles of the CTX-M-53 β-lactamases
| β-Lactamase | kcat (s−1) | Km (μM) | kcat/Km (s−1·μM−1) |
|---|---|---|---|
| Penicillin G | 135 | 10 | 13.5 |
| Amoxicillin | 85 | 40 | 2.1 |
| Ticarcillin | 10 | 18 | 0.5 |
| Piperacillin | 90 | 12 | 7.5 |
| Cephalothin | 2,000 | 122 | 16.4 |
| Cefuroxime | 292 | 80 | 3.6 |
| Cefotaxime | 585 | 180 | 3.2 |
| Cefpirome | 710 | 125 | 5.7 |
| Ceftazidime | 14 | 174 | 0.1 |
| Aztreonam | 4 | 14 | 0.3 |
