FIG. 1.
Results of time-kill curve studies performed by use of the in vitro kinetic model by applying both concentrations corresponding to the fCmax measured in humans after administration of a single dose of the antibiotic and simulated human serum elimination half-lives for the five antibiotics studied. The graph shows the change in CFU/ml in the culture flask over a 24-h period (mean and range, n = 2) for RIF, AZM, CXM, DCX, and GEN. The left ordinate displays the actual numbers of CFU/ml, and the right ordinate displays the changes in the numbers of log10 CFU/ml compared to the amount of bacteria present before the antibiotic was applied. The gray area displays decreased colony counts compared to the starting bacterial count, and the white area displays increased colony counts compared to the starting bacterial count.