TABLE 3.
Pfdhps genotypes and microsatellite markers from isolates collected in 1999 and 2006 to 2007
Yr of collection (no. of isolates) | No. of samples froma:
|
Pfdhps genotypeb
|
Microsatellite haplotype at the following locusc:
|
Haplogroup | Frequency | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CC | PC | Iquitos | S436A | A437G | K540E | A581G | A613S/T | −7.4 | −2.47 | −1.64 | 0.80 | 0.006 | 0.144 | 1.59 | 6.19 | 9.79 | |||
1999 (104) | 7 | 24 | S | G | E | G | A | 310 | 266 | 140 | 124 | 134 | 171 | 197 | 180 | 232 | DHPS-A1 | 0.3 | |
0 | 1 | S | G | K | G | A | 310 | 266 | 140 | 124 | 134 | 171 | 197 | 180 | 232 | DHPS-A1 | 0.01 | ||
19 | 3 | S | G | K | G | A | 310 | 266 | 140 | 124 | 134 | 171 | 197 | 178 | 232 | DHPS-A2 | 0.21 | ||
0 | 31 | S | A | K | A | A | 310 | 266 | 140 | 124 | 134 | 171 | 197 | 180 | 232 | DHPS-A1 | 0.3 | ||
14 | 5 | S | A | K | A | A | 285 | 247 | 140 | 130 | 134 | 190 | 189 | 180 | 220 | DHPS-B1 | 0.18 | ||
2006-2007 | 1 | S | G | E | G | A | 310 | 266 | 140 | 124 | 134 | 171 | 197 | 178 | 232 | DHPS-A2 | 0.016 | ||
(62) | 3 | S | G | E | G | A | 310 | 266 | 140 | 124 | 134 | 175 | 197 | 183 | 232 | DHPS-A3 | 0.05 | ||
7 | S | G | K | G | A | 310 | 266 | 140 | 124 | 134 | 171 | 197 | 178 | 232 | DHPS-A2 | 0.11 | |||
46 | S | A | K | A | A | 310 | 266 | 140 | 124 | 134 | 171 | 197 | 180 | 232 | DHPS-A1 | 0.74 | |||
1 | S | A | K | A | A | 310 | 266 | 140 | 124 | 134 | 171 | 197 | 232 | DHPS-Ad | 0.016 | ||||
2 | S | A | K | A | A | 310 | 247 | 140 | 130 | 134 | 190 | 189 | 180 | 222 | DHPS-B2 | 0.032 | |||
2 | S | A | K | A | A | 292 | 270 | 140 | 137 | 134 | 166 | 181 | 171 | 220 | DHPS-C1 | 0.032 |
CC, Caballococha; PC, Padre Cocha.
Boldface letters indicate mutations.
Microsatellite loci are named according to their positions (in kilobases) from the gene; negative positions are 5′ and positive positions are 3′ to the gene.
Even with an incomplete haplotype, this sample falls into the A group.