TABLE 1.

In vitro activities of CEM-101 and other antimicrobials against Mycoplasma and Ureaplasma species isolated from humans

Organism (no. of isolates) and antimicrobial	MIC range (μg/ml)	MIC50 (μg/ml)a	MIC90 (μg/ml)a
M. pneumoniae (36)
CEM-101	≤0.000000063-0.5	0.000032	0.000125
Azithromycin	≤0.000016 to ≥32	0.00025	0.0005
Telithromycin	0.000031 to ≥32	0.00025	0.001
Doxycycline	0.016-0.25	0.125	0.25
Levofloxacin	0.125-1	0.5	0.5
Linezolid	32-128	64	128
M. genitalium (5)
CEM-101	≤0.000032	NA	NA
Azithromycin	≤0.000032-0.005	NA	NA
Telithromycin	≤0.00003-0.00025	NA	NA
Doxycycline	≤0.008-0.031	NA	NA
Levofloxacin	0.125-1	NA	NA
Linezolid	4-128	NA	NA
M. fermentans (15)
CEM-101	≤0.008	≤0.008	≤0.008
Azithromycin	0.125-1	0.5	0.5
Telithromycin	0.002-0.031	≤0.008	0.016
Clindamycin	≤0.008-0.063	0.016	0.031
Doxycycline	0.016-0.5	0.125	0.5
Levofloxacin	≤0.008-0.25	0.031	0.125
Linezolid	0.5-4	1	4
M. hominis (13)
CEM-101	0.002-0.008	0.004	0.008
Azithromycin	0.5-4	4	2
Telithromycin	0.125-0.5	0.25	0.5
Clindamycin	≤0.008-0.031	≤0.008	0.016
Doxycycline	≤0.008-0.016	0.125	8
Levofloxacin	0.125-0.5	0.25	0.5
Linezolid	1-8	2	4
U. parvum (10)
CEM-101	0.002-0.031	0.008	0.016
Azithromycin	0.5-4	2	4
Telithromycin	0.008-0.063	0.063	0.125
Doxycycline	0.031-16	8	16
Levofloxacin	0.125-2	0.5	2
Linezolid	128 to >256	>256	>256
U. urealyticum (10)
CEM-101	0.004-0.063	0.008	0.031
Azithromycin	0.5-4	2	4
Telithromycin	0.016-0.25	0.063	0.25
Doxycycline	0.031-32	1	16
Levofloxacin	0.5-2	0.5	1
Linezolid	256 to >256	>256	>256

^aNA, not applicable.