TABLE 4.

Plasma PK of EDP-420 versus other marketed macrolides^a

Parameter	EDP-420	ERY	CLAR	TEL	AZI
Dose (mg)	400	500	400	400	500
Cmax (μg/ml)	0.54	2.00	0.78	0.80	0.40
AUC0-∞ (μg·h/ml)	14.40	7.70	7.52	3.09	3.39
t1/2 (h)	15.8	2.0	3.89
t1/2α (h)				2.13	11-14
t1/2β (h)				6.68	35-40

^aThe PK data for erythromycin (ERY), clarithromycin (CLAR), telithromycin (TEL), and azithromycin (AZI) were obtained from earlier studies (7, 18, 23, 32).